KMID : 1141920180340060286
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Annals of Coloproctology 2018 Volume.34 No. 6 p.286 ~ p.291
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Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection
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Park Jung-Ho
Park Hyoung-Chul Park Sung-Chan Oh Jae-Hwan Kim Duck-Woo Kang Sung-Bum Heo Seung-Chul
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Abstract
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Purpose: Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer.
Methods: From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS.
Results: The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1?134 months). A multivariate Cox regression revealed that female sex (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.19?1.90; P < 0.01), right-sided tumor location (HR, 1.65; 95% CI, 1.29?2.11; P < 0.01), lymphatic invasion (HR, 1.52; 95% CI, 1.08?2.15; P < 0.01) and a high (¡Ã0.4) metastatic lymph node ratio (HR, 3.72; 95% CI, 2.63?5.24; P < 0.01) were independent predictors of worse 5-year DFS. Female patients with RCC were 1.79 fold more likely to experience recurrence than male patients with LCC.
Conclusion: Female sex and right-sided tumor location are associated with higher tumor recurrence rates in patients with stage-IIIC colon cancers. Aggressive treatment and close surveillance should be planned for patients in these groups.
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KEYWORD
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Colonic neoplasms, Ascending colon, Descending colon, Prognosis, Recurrence
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